Hyaluronidase is an enzyme derived from Hymenoptera venom or some species of snake. Hyaluronidase containing substances depolymerize hyaluronic acid, commonly used as a filler in aesthetic medicine. Hyaluronidase locally degrades hyaluronic acid, which is later naturally excreted from the body.

The specialist, after excluding the contraindications, punctures the treatment site with a thin needle and injects the hyaluronidase preparation.

Before the procedure, an allergy test should also be carried out, which will exclude the patient’s allergy to the components of the preparation.

The first effects of the treatment are visible immediately, the total effect can be assessed after about 2-3 days. After the procedure, there may be slight bruising and redness, which disappears on its own after a few hours.

• poor tolerance to the hyaluronic acid given earlier
• unsightly filling with hyaluronic acid, e.g. asymmetry
• water retention at the treatment site
• clogging the lumen of a blood vessel with hyaluronic acipapules, and bumps after application
• too much filler

The treatment with hyaluronidase is unfortunately not intended for everyone – it can be seriously allergic. Therefore, excluded from the procedure are, among others people allergic to Hymenoptera venom (e.g. wasps and bees). Therefore, it is very important to consult a specialist before the procedure, where all contraindications will be discussed. It is also important that the person undergoing the procedure is surrounded by professional medical care in the event of unwanted complications. Contraindications for the procedure are also infections at the planned injection sites, pregnancy and any acute conditions of the body.